President Obama is expected to address the nation on Thursday to discuss the unprecedented changes that are sweeping the Middle East. The rising up of Arab citizens has rebuffed Osama bin Laden's message of extremism and violence - but also swept away many of the familiar underpinnings of U.S. influence in the region. In this new environment, the U.S. faces three sets of challenges: realigning our interests and values; offering practical assistance, not cookie-cutter solutions, to the problems at hand; and remaining focused, even in changed circumstances, on the core challenges of Middle East peace, terrorism, building new partnerships with new powers and dealing with Iran. Our most valuable tools are civilian - technology, private sector and personal ties, renewed diplomacy and above all showing by our example that we are ready to partner with those who are willing to partner with us.